FAVOURABLE PROGNOSTIC ROLE OF HIGH BASAL MAXIMAL STANDARDIZED UPTAKE VALUE IN FOLLICULAR LYMPHOMA

Introduction: Follicular Lymphoma (FL) is an indolent disease: despite the efficacy of treatment strategies in inducing remission, high risk patients relapse within two years and others on long term. Despite encouraging studies prognostic role Total Metabolic Tumor Volume (TMTV) SUVmax at baseline PET/CT needs to be better defined. Methods: Retrospective observational monocentric cohort study performed Sapienza University Rome. All affected by FL who underwent a basal staging were included. Patients fulfilled GELF criteria received different treatment, according guidelines clinical judgment. stratified assessed onset. Two subgroups identified compared terms PFS OS: A) Basal < 6; B) > 6. Results: Ninety-four included, 34 group A (36,2%) 60 B (63,8%). Five-year whole was 87,5%, 74,5% for 95% (p 0.005). Nevertheless, comparable groups (97%). correlation between observed FLIPI categories. In low-risk (48.3%) significantly superior term A, follow-up 92% 66,7% respectively 0.012) (Figure 1A-B). No significant association subgroup intermediate 0.180) high-risk 0.317). Multivariate analysis all parameters assessed, confirmed presence >6 as independent favorable factor PSF (OR 0.234; IC 0.58-0.934; p 0.04) well BM involvement diagnosis unfavorable (odds ratio [OR] 5.98; 1.5-23.3; 0.011). Was finally explored based least features considered indicator aggressive disease (bone marrow involvement, elevated LDH, β2-microglobulin, extra-nodal disease, bulky B-symptoms) 1D). Conclusion: Our data demonstrate predictor, especially with FL. Even without other factors, low tumor metabolic activity exhibit higher long-term probability. Baseline evaluation, its simple assessment, could help identifying late relapse, requiring strict and, potentially, MRD monitoring. Image B, C: relationship D: 2 factors b2-microglobulin, Keywords: Diagnostic Prognostic Biomarkers, PET-CT, Indolent non-Hodgkin lymphoma conflicts interests pertinent abstract.